Foslevodopa–Foscarbidopa subcutaneous infusion in Parkinson’s disease: a cross-cultural/cross-racial international multicentre comparative tolerability study (CRIM-FOS study)

Abstract

Advanced Parkinson’s disease (APD) often presents challenges such as irregular gastric absorption and delayed gastric emptying, leading to significant and unpredictable fluctuations in both motor and non-motor symptoms. Our study is a real-world, open-label study of the tolerability and efficacy of subcutaneous infusion of Foslevodopa/Foscarbidopa (FL/FC) focus on comparing White Caucasian patients and non-White patient cohorts. A database of 50 patients with APD across four international centers, for the FL/FC therapy program was examined and analysed for racial/ethnicity breakdown, motor, nonmotor and quality of life measures and tolerability using established criteria. Participants underwent assessments at 6 and 12 months, making this one of the largest global cross-racial Caucasian (62%) and non-Caucasian patients (38%) Statistical analyses were performed using IBM SPSS Statistics version 31, with significance set at p