Host specificity of the dickeya bacteriophage PP35 is directed by a tail spike interaction with bacterial o-antigen, enabling the infection of alternative non-pathogenic bacterial host

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Abstract

Dickeya solani is a recently emerged virulent bacterial potato pathogen that poses a major threat to world agriculture. Because of increasing antibiotic resistance and growing limitations in antibiotic use, alternative antibacterials such as bacteriophages are being developed. Myoviridae bacteriophages recently re-ranked as a separate Ackermannviridae family, such as phage PP35 described in this work, are the attractive candidates for this bacterial biocontrol. PP35 has a very specific host range due to the presence of tail spike protein PP35 gp156, which can depolymerize the O-polysaccharide (OPS) of D. solani. The D. solani OPS structure, →2)-β-D-6-deoxy-D-altrose-(1→, is so far unique among soft-rot Pectobacteriaceae, though it may exist in non-virulent environmental Enterobacteriaceae. The phage tail spike depolymerase degrades the shielding polysaccharide, and launches the cell infection process. We hypothesize that non-pathogenic commensal bacteria may maintain the population of the phage in soil environment.

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Kabanova, A. P., Shneider, M. M., Korzhenkov, A. A., Bugaeva, E. N., Miroshnikov, K. K., Zdorovenko, E. L., … Miroshnikov, K. A. (2019). Host specificity of the dickeya bacteriophage PP35 is directed by a tail spike interaction with bacterial o-antigen, enabling the infection of alternative non-pathogenic bacterial host. Frontiers in Microbiology, 10(JAN). https://doi.org/10.3389/fmicb.2018.03288

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