Dickeya solani is a recently emerged virulent bacterial potato pathogen that poses a major threat to world agriculture. Because of increasing antibiotic resistance and growing limitations in antibiotic use, alternative antibacterials such as bacteriophages are being developed. Myoviridae bacteriophages recently re-ranked as a separate Ackermannviridae family, such as phage PP35 described in this work, are the attractive candidates for this bacterial biocontrol. PP35 has a very specific host range due to the presence of tail spike protein PP35 gp156, which can depolymerize the O-polysaccharide (OPS) of D. solani. The D. solani OPS structure, →2)-β-D-6-deoxy-D-altrose-(1→, is so far unique among soft-rot Pectobacteriaceae, though it may exist in non-virulent environmental Enterobacteriaceae. The phage tail spike depolymerase degrades the shielding polysaccharide, and launches the cell infection process. We hypothesize that non-pathogenic commensal bacteria may maintain the population of the phage in soil environment.
CITATION STYLE
Kabanova, A. P., Shneider, M. M., Korzhenkov, A. A., Bugaeva, E. N., Miroshnikov, K. K., Zdorovenko, E. L., … Miroshnikov, K. A. (2019). Host specificity of the dickeya bacteriophage PP35 is directed by a tail spike interaction with bacterial o-antigen, enabling the infection of alternative non-pathogenic bacterial host. Frontiers in Microbiology, 10(JAN). https://doi.org/10.3389/fmicb.2018.03288
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