Objective: To establish the serum pattern of dimeric inhibins in normal girls during the newborn period and to examine its relationship with the postnatal gonadotropic surge. Design: Retrospective study. Setting: Division of endocrinology of a children's hospital. Patient(s): Thirty-one girls 4 to 65 days of age. Main Outcome Measure(s): Serum levels of FSH, LH, and inhibin A and B. Result(s): High serum concentrations of both dimeric inhibins were detected during the first weeks of life. Concentrations tended to decrease through the second month of age. Inhibin A and B concentrations positively correlated with age only during the first 2 weeks of life (r = .57, P<.05 and r = .70, P<.01, respectively). Inhibin A and B were positively and significantly correlated with LH (r = .57, P<.05 and r = .52, P<.05, respectively) and with each other (r = .68, P<.0001). No correlation was found between dimeric inhibins and FSH. Conclusion(s): The high inhibin concentrations observed in newborn girls, which indicate advanced follicular development and granulosa cell differentiation, may be useful markers for congenital gonadal disorders. Copyright © 2002 American Society for Reproductive Medicine.
Bergadá, I., Ballerini, G. M., Ayuso, S., Groome, N. P., Bergadá, C., & Campo, S. (2002). High serum concentrations of dimeric inhibins A and B in normal newborn girls. Fertility and Sterility, 77(2), 363–365. https://doi.org/10.1016/S0015-0282(01)02965-X