UV SPECTROPHOTOMETRIC METHOD FOR THE ESTIMATION OF NORETHINDRONE IN IMMEDIATE RELEASE TABLET

Abstract

A modification of the U.S.P. dissolution method for the quantitative determination of Norethindrone in solid oral tablet is proposed. This modification consists of the use of varying concentration of sodium lauryl sulfate in dissolution media (0.1 N Hydrochloric acid) and use of UV spectroscopy instead of HPLC for analysis of samples. The rate and extent of dissolution of Norethindrone was much greater when high concentration of sodium lauryl sulfate 1.0% w/v was used. Different dissolution trials were conducted on a pre-optimized formulation. The proposed method has been applied successfully for the analysis of the drug in the tablet dosage form. The percentage assay of Norethindrone in tablet was 99.95%. This method has the advantage of quicker turnaround time of sample analysis and less cost involved. It can serve as a surrogate for HPLC method for the routine use in quality control laboratories of pharmaceutical industry.