Catalytic asymmetric fluorination comes of age

Abstract

(Chemical Equation Presented) Gimme an F: Ever since the first asymmetricfluorination reagents were reported in 1988, the enantioselective introduction of a C-F bond at a stereogenicc enter has emerged as a major objective in organic chemistry. Newly published results on the enantioselective fluorination of malonates (see scheme) are put into context in this Highlight. NFSI = N-fluorodibenzenesulfonimide. © 2008 Wiley-VCH Verlag GmbH & Co. KGaA.