A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol

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Abstract

We discuss a case of severe respiratory depression in a child, with ultrarapid CYP2D6 genotype and obstructive sleep apnea syndrome, after taking tramadol for pain relief related to a day-case tonsillectomy.

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Orliaguet, G., Hamza, J., Couloigner, V., Denoyelle, F., Loriot, M. A., Broly, F., & Garabedian, E. N. (2015). A case of respiratory depression in a child with ultrarapid CYP2D6 metabolism after tramadol. Pediatrics, 135(3), e753–e755. https://doi.org/10.1542/peds.2014-2673

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