Murine Acute Pneumonia Model of Pseudomonas aeruginosa Lung Infection

Abstract

Animal infection models play significant roles in studying bacterial pathogenic mechanisms, host pathogen interaction as well as evaluating drug and vaccine efficacies. We have been utilizing an acute pneumonia model to study bacterial colonization in lungs and assess virulence to the host by determination of bacterial loads and survival assays, as well as examine the bacterial gene expression in vivo. Additionally, the hosts immune response to the pathogen can be explored through this infection model.