Studying the Physical and Biological Characteristics of Denture Base Resin PMMA Reinforced With ZrO2 and TiO2 Nanoparticles

Abstract

Polymethyl methacrylate (PMMA) suffers from poor mechanical properties that limit its application in the biomedical field. In this study, PMMA was reinforced with zirconium dioxide (ZrO2) and titanium dioxide (TiO2) nanoparticles; subsequently, the hardness, porosity, biocompatibility, bacterial adhesion, and colonization of the reinforced PMMA with various oxide nanoparticles were characterized. The results of this study indicated that reinforced material inhibits bacterial growth and decreases bacterial adhesion by decreasing porosity and increasing PMMA hardness. Based on the findings, 3 wt% PMMA-ZrO2 and 3 wt% PMMA-ZrO2 -TiO2 composites significantly inhibited bacterial growth and adherence while maintaining hemolysis PT and INR and enhancing the hardness and decreasing porosity.