Aromatic enamide/ene metathesis toward substituted indoles and its application to the synthesis of indomethacins

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Abstract

A. steric and electronic effect: on enamide/ene metathesis, a novel preparation of 2-substituted indoles and 3-substituted indoles using enamide-ene metathesis as a key reaction, and its application to the synthesis of indoniethacin are described. © Wiley-VCH Verlag GmbH & Co. KGaA.

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Kasaya, Y., Hoshi, K., Terada, Y., Nishida, A., Shuto, S., & Arisawa, M. (2009). Aromatic enamide/ene metathesis toward substituted indoles and its application to the synthesis of indomethacins. European Journal of Organic Chemistry, (27), 4606–4613. https://doi.org/10.1002/ejoc.200900520

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