Balancing the bipotential gonad between alternative organ fates: A new perspective on an old problem

125Citations
Citations of this article
89Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

The embryonic gonads give rise to one of two morphologically and functionally different organs, a testis or an ovary. Sex determination is the embryonic process that determines the developmental fate of the gonad. In mammals, sex determination is regulated by a DNA binding protein encoded on the Y chromosome, Sry, and it's downstream mediator, Sox9, which trigger testis determination in the bipotential gonad. However, evidence suggests that the extracellular signals. Fgf9 and Wnt4, are also required to establish divergent organogenesis of the gonad. In this review, we discuss how these extracellular signals interface with cell-autonomous factors to determine the fate of the mammalian gonad, and we derive a model that could provide a molecular explanation for testis determination in vertebrates where Sry is absent. © 2006 Wiley-Liss, Inc.

Cite

CITATION STYLE

APA

Kim, Y., & Capel, B. (2006, September). Balancing the bipotential gonad between alternative organ fates: A new perspective on an old problem. Developmental Dynamics. https://doi.org/10.1002/dvdy.20894

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free