Nowadays, the metagenomic approach has been a very important tool in the discovery of new viruses in environmental and biological samples. Here we discuss how these discoveries may help to elucidate the etiology of diseases and the criteria necessary to establish a causal association between a virus and a disease.
Castrignano, S. B., & Nagasse-Sugahara, T. K. (2015). The metagenomic approach and causality in virology. Revista de Saude Publica. Universidade de Sao Paulo. https://doi.org/10.1590/S0034-8910.2015049005475