EFFECTIVE DRUG DELIVERY SYSTEMS IN LOCALIZED BREAST CANCER THERAPIES: INJECTABLE HYDROGELS

Abstract

Objective: Breast cancer is the most common cancer in women worldwide and is a critical health problem that requires continuous research for early detection and development of effective treatment strategies. There is a need to develop innovative treatment modalities to overcome the limitations of conventional chemotherapy such as non-specific targeting, systemic toxicity, drug resistance and limited drug penetration. As drug delivery systems, injectable hydrogels have come to the forefront in local cancer treatments due to their biodegradable, biocompatible, design-adjustable physicochemical properties as well as their ability to provide highly efficient loading and release of the active substance. Injectable biodegradable hydrogels are critical in preventing cancer recurrence and metastasis, especially in the post surgical treatment process. In this review, we aimed to evaluate the structures, types, cancer treatment applications and anticancer therapeutic efficacy of injectable hydrogels. Result and Discussion: In this review, the structures of injectable hydrogels as pharmaceutical drug delivery systems, their applications in breast cancer treatments and their anticancer therapeutic efficacy for breast cancer were discussed.