Association of total testosterone, free testosterone, bioavailable testosterone, sex hormone binding globulin, and hypertension

Abstract

Low testosterone has been inversely associated with hypertension. Our objective was to determine the associations between total testosterone (TT), free testosterone (FT), bioavailable testosterone (BioT), sex hormone binding globulin (SHBG), and hypertension. Two hundred fifty-Three men were enrolled in this study. TT and SHBG were measured by chemiluminescent immunoassay, and FT and BioT were calculated. Hypertension was defined as systolic blood pressure (SBP) 140 mm Hg and/or diastolic blood pressure (DBP) 90 mm Hg. Our results showed that hypertensive men had higher SHBG levels, and lower FT and BioT, compared to normotensive men. FT and BioT were inversely associated with SBP and DBP after adjusting for covariates (age, smoking, alcohol consumption, and physical activity). Furthermore, there was a significant decrease in the odds ratios for hypertension in the third and fourth quartiles of BioT and FT, compared to the lowest quartile before and after adjusting for covariates. In contrast, the OR for hypertension in the third quartile of SHBG was lower than the highest quartile. Our data show that FT and BioT are inversely correlated with SBP, DBP, and hypertension in men. Abbreviations: BioT = bioavailable testosterone, DBP = diastolic blood pressure, FT = free testosterone, JNC 7 = the Seventh Report of the Joint National Committee, MetS = metabolic syndrome, ORs = odds ratios, SBP = systolic blood pressure, SHBG = sex hormone binding globulin, TT = total testosterone.