Association of an oral formulation of angiotensin-(1-7) with atenolol improves lipid metabolism in hypertensive rats

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Abstract

The β-adrenergic blockers and antagonists of the renin-angiotensin system (RAS) are among the drugs that present better results in the control of cardio-metabolic diseases. The aim of the present study was to evaluate the effect of the association of the β-blocker, atenolol, and an oral formulation of Ang-(1-7) on lipid metabolism in spontaneously hypertensive rats (SHR). The main results showed that SHR treated with oral formulation of Ang-(1-7) in combination to atenolol have an improvement of lipid metabolism with a reduction of total plasma cholesterol, improvement of oral fat load tolerance and an increase in the lipolytic response stimulated by the β-adrenergic agonist, isoproterenol, without modification of resting glucose or insulin sensitivity in adipocytes. In conclusion, we showed that administration of an Ang-(1-7) oral formulation in association with a β-blocker induces beneficial effects on dyslipidemia treatment associated with hypertension. © 2013 Elsevier Inc. All rights reserved.

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Santos, C. F. F., Santos, S. H. S., Ferreira, A. V. M., Botion, L. M., Santos, R. A. S., & Campagnole-Santos, M. J. (2013). Association of an oral formulation of angiotensin-(1-7) with atenolol improves lipid metabolism in hypertensive rats. Peptides, 43, 155–159. https://doi.org/10.1016/j.peptides.2013.03.009

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