Isoflavonoids from desmodium heterophyllum aerial parts

Abstract

Five isoflavanoids including one new, (3R)-2',4',5,7-tetrahydroxy-6-methylisoflavanone (1), were isolated from the aerial parts of Desmodium heterophyllum. Their structures were elucidated using spectroscopic methods. Their inhibitory effects on digestive enzymes α-glucosidase and α-amylase were evaluated. Genistein (5) and dalbergioidin (2) inhibited both enzymes. Their IC50 values were found at 110.4 and 162.8 μM for α-amylase, and at 257.3 and 412.6 μM for α-glucosidase, respectively.