P1526Influence of energy drinks on hemodynamic parameters - randomized double-blind placebo controlled cross-over study

Abstract

Introduction: An energy drink (ED) is a type of beverage containing stimulant drugs, caffeine, taurine, which is marketed as providing mental and physical stimulation. The popularity of product is increasing especially among teenagers and young adults. Some research suggest that its consumption may have negative effect on cardiovascular system. Aim: Assessment of the influence of single dose of ED on blood pressure, heart rate, ECG, cardiac output and vascular compliance in healthy volunteers. Materials and methods: A randomized doubleblind placebo controlled crossover study was conducted on 18 healthy volunteers (7 female, 11 male, mean age 23,67±1,19). Subjects received: 500 ml of energy drink containing 160mg of caffeine, 2g of taurine and 50mg of guarana or 500ml of placebo (P). Participants drank beverages in random order during two different meetings. Drinks did not differ in taste, smell and color. In all participants before and after consumption of a drink, in the same sequence and time intervals following procedures were performed: peripheral and central systolic and diastolic blood pressure (SBP and DBP) measurement, ECG recording, echocardiography, and pulse wave velocity (PWV) analysis. Results: ED consumption was related with significant increase of SBP in 75 min of observation compared to placebo (ΔSBP for ED 5,7±10,2 mmHg vs 0,3± 7,2 mmHg for P, p=0,03). ED caused also increase in central SBP (107,8±13,2 vs 115,6±12,1 mmHg p=0,0005), and central DBP (73,9±11,9 vs 78,1±10,2 mmHg p=0,02). However comparison between placebo and ED revealed no significant differences in these parameters. Tendency for increase of PWV in ED group was observed (ΔPWV for ED 0,6±0,7 m/s vs 0,2±0,6 m/s for P, p=0,10), and significant reduction of augmentation index was noted (ΔAI for ED 10,5± 17,9% vs 7,55±17,7% for P, p=0,005). The ECG parameters (HR, PQ, QRS and QTc intervals, axis of P wave, QRS complex, T wave) did not reveal statistical differences between groups. There were no differences in echocardiographically determined cardiac output and LVEF. Conclusions: Single dose ED consumption increases peripheral and central SBP. This effect is probably mediated by vascular wall properties and not by cardiac performance. Further studies on the influence of chronic ED consumption on central and peripheral hemodynamic parameters are needed.