Successful treatment of a patient with glioblastoma and a germline POLE mutation: Where next?

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Abstract

Hypermutation and elevated neoantigen count in glioblastoma occurred in a patient harboring a germline POLE mutation and are associated with a clinical and antitumor immune response to PD-1 blockade.

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Snyder, A., & Wolchok, J. D. (2016). Successful treatment of a patient with glioblastoma and a germline POLE mutation: Where next? Cancer Discovery, 6(11), 1210–1211. https://doi.org/10.1158/2159-8290.CD-16-1056

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