Candidate Tumor-Suppressor Genes MTS1 (p16INK4A) and MTS2 (p15INK4B) Display Frequent Homozygous Deletions in Primary Cells from T-But Not from B-Cell Lineage Acute Lymphoblastic Leukemias

Abstract

Using a Southern blot approach, deletions of MTS1 (multiple tumor-suppressor gene 1) and MTS2 (multiple tumor-suppressor gene 2) candidate tumor-suppressor genes have been studied in primary neoplastic cells from 55 acute lymphoblastic leukemia (ALL) patients. Homozygous MTS1 deletions were found in 20 of 24 T-ALL cases and in only 2 of 31 B-lineage cases (P < .001). The deletions involved MTS1 and MTS2 in most cases. Homozygous MTS2 deletions were observed in 16 of 24 T-ALL cases and in 1 of 31 B-lineage ALLs (P