Presence of a Na+/H+ exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs

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Abstract

Acidocalcisomes are acidic vacuoles present in trypanosomatids that contain most of the cellular calcium. The data presented here demonstrate that Leishmania donovani acidocalcisomes possess a Na+/H+ exchanger. 3,5- Dibutyl-4-hydroxytoluene, in the concentration range of 0-20 μM, inhibited the Na+/H+ exchanger, and strongly stimulated the activity of the vacuolar H+-ATPase responsible for vacuolar acidification. As occurs with Na+, the cationic anti-leishmanial drugs pentamidine, WR-6026, and chloroquine promoted a fast and extensive alkalization of the L. donovani acidocalcisomes. (C) 2000 Federation of European Biochemical Societies.

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Vercesi, A. E., Rodrigues, C. O., Catisti, R., & Docampo, R. (2000). Presence of a Na+/H+ exchanger in acidocalcisomes of Leishmania donovani and their alkalization by anti-leishmanial drugs. FEBS Letters, 473(2), 203–206. https://doi.org/10.1016/S0014-5793(00)01531-3

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