DAS-444Ø6-6 soybean was genetically engineered (GE) to withstand applications of three different herbicides. Tolerance to glufosinate and glyphosate is achieved through expression of the phosphinothricin acetyltransferase (PAT) and double-mutated maize 5-enolpyruvyl shikimate-3-phosphate synthase (2mEPSPS) enzymes, respectively. These proteins are expressed in currently commercialized crops and represent no novel risk. Tolerance to 2,4-dichlorophenoxyacetic acid (2,4-D) is achieved through expression of the aryloxyalkanoate dioxygenase 12 (AAD-12) enzyme, which is novel in crops. The safety of the AAD-12 protein and DAS-444Ø6-6 event was assessed for food and feed safety based on the weight of evidence and found to be as safe as non-GE soybean.
Herman, R. A., Ekmay, R. D., Schafer, B. W., Song, P., Fast, B. J., Papineni, S., … Juberg, D. R. (2018, April 1). Food and feed safety of DAS-444Ø6-6 herbicide-tolerant soybean. Regulatory Toxicology and Pharmacology. Academic Press Inc. https://doi.org/10.1016/j.yrtph.2018.01.016