Gene Regulation by Nucleoporins and Links to Cancer

80Citations
Citations of this article
220Readers
Mendeley users who have this article in their library.

Abstract

Nuclear pore complexes (NPCs) composed of ∼30 individual nucleoporins form huge macromolecular assemblies in the nuclear envelope, through which bidirectional cargo movement between the nucleus and cytoplasm occurs. Beyond their transport function, NPCs can serve as docking sites for chromatin and thereby contribute to the organization of the overall topology of chromosomes in conjunction with other factors of the nuclear envelope. Recent studies suggest that gene-NPC interactions may promote both transcription and the definition of heterochromatin-euchromatin boundaries. Intriguingly, several nucleoporins were linked to cancer, mostly in the context of chromosomal translocations, which encode nucleoporin chimeras. An emerging concept is that tumor cells exploit specific properties of nucleoporins to deregulate transcription, chromatin boundaries, and essential transport-dependent regulatory circuits. This review outlines new mechanistic links between nucleoporin function and cancer pathogenesis. © 2010 Elsevier Inc. All rights reserved.

Cite

CITATION STYLE

APA

Köhler, A., & Hurt, E. (2010, April 9). Gene Regulation by Nucleoporins and Links to Cancer. Molecular Cell. https://doi.org/10.1016/j.molcel.2010.01.040

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free