Relations Between Replication and Transcription

Abstract

In the cell, RNA polymerase (RNAP) and the replisome share the same template DNA for their respective functions. The rate of replication is typically 20 times faster than transcription and six or more replication forks may be present at the same time on the chromosome (Gotta et al. 1991; Hirose et al. 1983). This implies that collisions between the two machineries are inevitable. In this chapter we will discuss the recent findings on the outcome of collisions between transcription and replication and their consequences, as well as cooperation between the two machineries