Efficient synthesis of spirobarbiturates and spirothiobarbiturates bearing cyclopropane rings by rhodium(ii)-catalyzed reactions of cyclic diazo compounds

Abstract

Rhodium(II)-catalyzed reactions of cyclic diazo compounds derived from barbituric acid and thiobarbituric acid with a variety of styrene moieties were examined. These reactions provide rapid synthetic routes to the preparations of spirobarbiturates and spirothiobarbiturates bearing cyclopropane rings.