Relationship Between Estrogen Receptor Co-regulators and Histological Grade in Estrogen-Dependent Invasive Breast Cancer

Abstract

The study aims to assess the relationship between level expression co-regulators of estrogen receptor (SRC1, CBP/p300, NCoR, SMRT) in estrogen-dependent invasive breast cancer with histological grade. The other aims of study to evaluate the interaction between p53, Ki-67, Her-2/Neu expression and co-regulators with the histological grade. Analysis of these relationships will result in deeper understanding on the molecular basis of breast cancer incidence which can be associated with prognosis and prediction of the disease and evaluation of the targeted therapy in breast cancer. The co-regulators and p53, Ki-67, Her-2/Neu were examined using immuno-histochemical technique toward paraffin block of 85 patients with estrogen receptor (ER) α positive. Relationships between these targets and histological grade were analyzed. We observed that SRC1 was associated with a high degree of malignancy and NCoR had a significant correlation with a low degree of malignancy. Interaction of SRC1 and NCoR with p53, Ki-67 and Her-2/Neu is significantly associated with the high degree of malignancy. This study provided evidence that SRC1 and NCoR were the independent prognostic factors. SRC1 was associated with the high grade malignancy (poor differentiation and in the other hand, the NCoR was associated with well differentiation histopathology. High expression of p53, Ki-67 and Her2/Neu which interact with SRC1 and NCoR were associated with a high degree malignancy.