Substituent effect of camphor sulfonamide ligand on the asymmetric addition of diethylzinc to aldehyde

Abstract

A variety of camphor sulfonamide ligands were synthesized and employed in the addition of diethylzinc to aldehydes. The influences of substitution patterns, electronic property, reaction substrates, reaction solvents and temperature were studied. After optimization, the best reaction condition was determined and applied to this addition reaction, giving the corresponding products in high yields with up to 83% ee. ©ARKAT.