The most important of nature of biomarker is changes. Blood is under strict homeostatic control which means changes tend to be removed from blood. Urine is a partial filtrate of blood, reflects systemic physiology but with no homeostatic mechanism. However, changes induced directly into the blood can be more sensitively detected in urine than in blood itself. This indicates that urine may serve as a source for more sensitive detection of protein biomarkers than blood.
CITATION STYLE
Li, M. (2015). Urine reflection of changes in blood. Advances in Experimental Medicine and Biology, 845, 13–19. https://doi.org/10.1007/978-94-017-9523-4_2
Mendeley helps you to discover research relevant for your work.