Ni-catalyzed hydroarylation of alkynes with unactivated β-C(sp2)−H bonds

Abstract

Hydroarylation of alkynes with unactivated C(sp2)−H bonds via chelated C−H metalation mainly occurs at γ-position to the coordinating atom of directing groups via stable 5-membered metallacycles, while β-C(sp2)−H bond-involved hydroarylation has been a formidable challenge. Herein, we used a phosphine oxide-ligated Ni−Al bimetallic catalyst to enable β-C−H bond-involved hydroarylations of alkynes via a rare 7-membered nickelacycle.