Similarity searches in genome-wide numerical data sets

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Abstract

We present psi-square, a program for searching the space of gene vectors. The program starts with a gene vector, i.e., the set of measurements associated with a gene, and finds similar vectors, derives a probabilistic model of these vectors, then repeats search using this model as a query, and continues to update the model and search again, until convergence. When applied to three different pathway-discovery problems, psi-square was generally more sensitive and sometimes more specific than the ad hoc methods developed for solving each of these problems before. © 2006 Glazko et al; licensee BioMed Central Ltd.

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Glazko, G., Coleman, M., & Mushegian, A. (2006, May 30). Similarity searches in genome-wide numerical data sets. Biology Direct. https://doi.org/10.1186/1745-6150-1-13

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