Kinetic release study of diabetes mellitus drug encapsulated on chitosan alginate matrix

Abstract

One way of the release control of the glibenclamide is the process of encapsulation using a blend of calcium alginate✉chitosan polymer with the addition of tween 80 surfactants. The resulting microparticles were analyzed for encapsulation efficiency, dissolution test in gastric and artificial intestinal pH solutions, functional groups, and surface morphology. The encapsulation efficiency showed that the Tween 80 with a concentration of 4% can produce the highestencapsulation efficiency of 65,2568%. The kinetic release of glibenclamide encapsulated on intestinal medium showed that the amount of glibenclamide dissolved in the gastric medium is lower than in the intestinal medium so that it can prevent gastric irritation by the mechanism of glibenclamide release through a combination of diffusion and erosion. The FT✉IR spectra of the glibenclamide, alginate, chitosan, and glibenclamideencapsulated on the matrix showed that glibenclamide is only trapped physically in the alginate-chitosan matrix. SEM test results show that the surface morphology of the glibenclamide is encapsulated smooth, porous small and there is no agglomeration.