Two-stage revision of infected total knee replacements using articulating cement spacers and short-term antibiotic therapy

Abstract

We present a series 48 patients infected total knee replacements managed by the use of articulating cement spacers and short-term parenteral antibiotic therapy in the post-operative period. All patients had microbiological and/or histological confirmation of infection at the first stage of their revision. They all underwent re-implantation and had a mean follow-up of 48.5 months (26 to 85). Infection was successfully eradicated in 42 of the 48 patients (88%). Six had persistent infection which led to recurrence of symptoms and further surgery was successful in eliminating infection in four patients. These rates of success are similar to those of other comparable series. We conclude that protracted courses of intravenous antibiotic treatment may not be necessary in the management of the infected total knee replacement. In addition, we analysed the microbiological, histological and serological results obtained at the time of re-implantation of the definitive prosthesis, but could not identify a single test which alone would accurately predict a successful outcome. ©2006 British Editorial Society of Bone and Joint Surgery.