Understanding miR-200c: an Important Player in Resistance to Cancer Treatment

Abstract

One of the biggest obstacles to successful cancer treatment is still therapeutic resistance, which frequently leads to recurrence and unsatisfactory clinical outcomes. MicroRNA-200c (miR-200c), one of several molecular regulators, has grown into a crucial modulator of treatment efficacy by affecting processes including apoptosis, drug efflux, epithelial-mesenchymal transition, and cancer stem cell properties. Despite extensive research on miR-200c's roles in drug resistance, there is lack of comprehensive reviews summarizing these findings. This review gathers the most recent data on the complex functions of miR-200c in mediating chemotherapy and radiotherapy resistance across various cancer types. Its potential clinical aspects as a biomarker and therapeutic target are further discussed. Finally, existing knowledge gaps are outlined, and future research directions are proposed to support development of miR-200c-based strategies for overcoming therapeutic resistance in cancer.