Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice

4Citations
Citations of this article
9Readers
Mendeley users who have this article in their library.

Abstract

Background: Vitamin A and its derivatives (retinoids) are crucial for the development, maintenance and morphogenesis of the central nervous system (CNS). Although motor impairment has been reported in postnatal vitamin A depletion rodents, the effect of vitamin A depletion on homeostasis maintaining capability in response to external interference is not clear.Methods: In the current study, we measured the effect of vitamin A depletion on motor ability and pain sensitivity under two different conditions: 1. prior to any injection and 2. after the injection of an N-methyl-D-aspartate (NMDA) receptor antagonist (MK-801).Results: Vitamin A depletion mice showed decreased body weight, enhanced locomotor activity, increased rearing and less tail flick latency. Vitamin A depletion also induced hypersensitivity of stereotypy, ataxia, rearing, and tail flick latency to MK-801, but hyposensitivity of locomotion to MK-801.Conclusions: These findings suggest that vitamin A depletion affect broad basal behavior and disrupt homeostasis maintaining capability in response to glutamate perturbation. We provide a useful animal model for assessing the role of vitamin A depletion in regulating animal behavior, and for detecting how neurotransmitter pathways might be involved in vitamin A depletion related behavioral abnormalities. © 2010 Zhang et al; licensee BioMed Central Ltd.

Cite

CITATION STYLE

APA

Zhang, M., Ji, B., Zou, H., Shi, J., Zhang, Z., Li, X., … Wan, C. (2010). Vitamin A depletion alters sensitivity of motor behavior to MK-801 in C57BL/6J mice. Behavioral and Brain Functions, 6. https://doi.org/10.1186/1744-9081-6-7

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free