We report a 47-year-old male stroke patient with nasopharyngeal cancer (NPC) and protein C deficiency. The patient was diagnosed with NPC and received a complete course of radiotherapy. Infarction stroke occurred 28 months after radiotherapy and magnetic resonance imaging of the brain confirmed the diagnosis. Carotid duplex sonography showed 50-79% stenosis in his left internal carotid artery. Coagulation profiles indicated protein C deficiency. After medical treatment and rehabilitation, the patient regained the ability to walk and he could perform most of his daily activities. Radiotherapy-induced carotid stenosis is an exacerbating feature of stroke in patients with protein C deficiency. We suggest early carotid duplex sonography and survey of the coagulation profile to prevent a stroke in patients with NPC. © 2009 Formosan Medical Association & Elsevier.
Y.-N., C., T.-G., W., & C.-W., C. (2009). Early-onset Stroke in a Patient With Nasopharyngeal Cancer Associated With Protein C Deficiency. Journal of the Formosan Medical Association. C.-W. Chang, Department of Physical Medicine and Rehabilitation, National Taiwan University Hospital, Taipei, Taiwan (Republic of China). E-mail: firstname.lastname@example.org: Elsevier Ltd (Langford Lane, Kidlington, Oxford OX5 1GB, United Kingdom). Retrieved from http://ovidsp.ovid.com/ovidweb.cgi?T=JS&PAGE=reference&D=emed9&NEWS=N&AN=2009377416