Antioxidants Activity Assessment and Utilization of Banana Peels to Attenuate the Diabetes Mellitus

Abstract

Diabetes is the primary metabolic disorder listed among the top 10 death-causing diseases. The complete cure of diabetes is impossible, but the prevention and maintenance of glucose levels can reduce the diabetes severity. Objectives: To utilize the banana peel extracts to evaluate their antioxidant attributes and capability to attenuate diabetes. Methods: The antioxidant properties were assessed by measuring the DPPH, total phenolic contents (TPC), and total flavonoid contents (TFC) in ethanol, methanol, and acetone solutions. Moreover, the renal functional tests (Serum creatinine, serum urea, and BUN) and liver function tests (ALT, ASP, Serum Albumin, and total proteins) were also conducted during the 21 days experimental study in diabetes-induced (via Streptozotocin: 350 mg/kg) male Albino Wister rats. Results: The results indicated that the DPPH, TPC, and TFC contents were higher in methanol solution, i.e., 74.20±0.98%, 54.78±0.69mg GAE/g, and 39.48±0.37mg GAE/g respectively. Moreover, the results indicated that the unripe, ripe, and overripe significantly reduced liver and renal function parameters in diabetic rats. Conclusions: Banana peels have prominent potential to prevent diabetes-linked variables due to their higher antioxidant activity.