DIARREA AGUDA DEL LACTANTE. ESTUDIO CLINICO BACTERIOLOGICO COMPARATIVO EN GRUPOS TRATADOS CON BACTRIM, FUROXONA Y SIN MEDICAMENTO ANTIINFECCIOSO INTESTINAL

Abstract

Intestinal antibacterial therapy was clinically and bacteriologically evaluated in 100 infants affected with acute diarrhea and dehydration. Infants with parenteral infection or severe malnutrition were excluded. Fifty patients were treated with Bactrim (co trimoxazole): the dose was 40 mg/kg/day on the 1st day and 25 mg/kg/day from the 2nd to the 6th day. Fifty patients were treated with Furaxone (furazolidone): the dose was 10 mg/kg/day from the 1st to the 6th day. Twenty patients did not receive any antibacterial drug. General treatment, water, electrolytes and diet were similar in all patients. Intestinal pathogens were isolated in 27.5%, E. coli enteropathogenic organisms being the most frequently isolated. Probable intestinal pathogens were isolated in 24.2%. E. histolytica was isolated in 2 patients. Good clinical results were obtained in patients treated with co trimoxazole and furazolidone (80% and 74% respectively). Poor clinical results occurred in patients without specific treatment (40%). Good bacteriological results were also obtained in patients treated with both the drugs, but these were inferior to the clinical results. Poor bacteriological results occurred in patients who received no antibacterial treatment, 22.2% of the patients still showing residual intestinal pathogens. The authors believe co trimoxale to be very effective in the treatment of acute infantile diarrhea; toleration is good and no side effects were seen.