A Case of Apocrine Carcinoma Arising in a Sebaceous Naevus: Detection of HRAS G13R Mutation

Abstract

RAS mutations are known pathogenic genomic alterations in a sebaceous naevus (SN) (1). Secondary tumours of SN are mostly follicular tumours and adnexal gland tumours (2), and some carry RAS mutations (1). We describe here a case of apocrine carcinoma (AC) with an HRAS muta-tion that developed as a secondary tumour of a latent SN. and arises sporadically or originates from specific con-ditions, such as apocrine adenomas, accessory breast tissues, or SN. AC on the scalp should be differentiated from metastatic breast cancer. Moreover, it is necessary to determine whether AC on the scalp developed from an SN, because wide resection including the SN is desir-.