Sildenafil in the treatment of Raynaud's phenomenon resistant to vasodilatory therapy

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Abstract

Background - Vasodilatory therapy of Raynaud's phenomenon represents a difficult clinical problem because treatment often remains inefficient and may be not tolerated because of side effects. Methods and Results - To investigate the effects of sildenafil on symptoms and capillary perfusion in patients with Raynaud's phenomenon, we performed a double-blinded, placebo-controlled, fixed-dose, crossover study in 16 patients with symptomatic secondary Raynaud's phenomenon resistant to vasodilatory therapy. Patients were treated with 50 mg sildenafil or placebo twice daily for 4 weeks. Symptoms were assessed by diary cards including a 10-point Raynaud's Condition Score. Capillary flow velocity was measured in digital nailfold capillaries by means of a laser Doppler anemometer. While taking sildenafil, the mean frequency of Raynaud attacks was significantly lower (35±14 versus 52±18, P=0.0064), the cumulative attack duration was significantly shorter (581±133 versus 1046±245 minutes, P=0.0038), and the mean Raynaud's Condition Score was significantly lower (2.2±0,4 versus 3.0±0.5, P=0.0386), Capillary blood flow velocity increased in each individual patient, and the mean capillary flow velocity of all patients more than quadrupled after treatment with sildenafil (0.53±0.09 versus 0.13±0.02 mm/s, P=0.0004). Two patients reported side effects leading to discontinuation of the study drug. Conclusions - Sildenafil is an effective and well-tolerated treatment in patients with Raynaud's phenomenon. © 2005 American Heart Association, Inc.

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APA

Fries, R., Shariat, K., Von Wilmowsky, H., & Böhm, M. (2005). Sildenafil in the treatment of Raynaud’s phenomenon resistant to vasodilatory therapy. Circulation, 112(19), 2980–2985. https://doi.org/10.1161/CIRCULATIONAHA.104.523324

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