Novel molecular insights and new therapeutic strategies in osteosarcoma

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Abstract

Osteosarcoma (OS) is one of the most prevalent malignant cancers with lower survival and poor overall prognosis mainly in children and adolescents. Identifying the molecular mechanisms and OS stem cells (OSCs) as new concepts involved in disease pathogenesis and progression may potentially lead to new therapeutic targets. Therefore, therapeutic targeting of OSCs can be one of the most important and effective strategies for the treatment of OS. This review describes the new molecular targets of OS as well as novel therapeutic approaches in the design of future investigations and treatment.

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Otoukesh, B., Boddouhi, B., Moghtadaei, M., Kaghazian, P., & Kaghazian, M. (2018, October 16). Novel molecular insights and new therapeutic strategies in osteosarcoma. Cancer Cell International. BioMed Central Ltd. https://doi.org/10.1186/s12935-018-0654-4

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