O2-03-03: Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging of frontotemporal dementia complex

  • Buyatti D
  • Russo G
  • Bagnati P
  • et al.
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Background: The diagnosis of the syndrome called frontotemporal dementia complex involves the distinction between three clinical subtypes: the behavioral variant (FTDbv), the semantic dementia (SD) and nonfluent primary progressive aphasia (PNFA). The CDR(clinical dementia rating scale) is a tool designed to quantify the severity of dementia symptoms and is also useful to assess disease progression, particularly in the dementia syndrome due to Alzheimer's disease. David Knopman and cols developed a new version of the scale by adding two extra domains (behavioral and language) in order to detect symptoms and assess progression in the Frontotemporal Dementia complex. Our goal is to adapt and validate the FTDL-Modified CDR in our setting and language. Methods: 45 patients with cognitive impairment due to Alzheimer's disease, 43 Frontotemporal dementia and 40 cognitive healthy people from the Cognitive and Neuropsychiatry department of FLENI were evaluated using the Spanish version of the FTDL-modified CDR. The diagnosed was performed in all cases according to specific international diagnosis criteria. All patients were referred to the study by their personal neurologist. They underwent a neuropsychological assessment and brain MRI was performed. The adapted version of the scale was administered by a blind rater who interviewed patients together with patient's caregiver. Results: 43 FTLD patients, from the three clinical subtypes (FTDbv, SD and PNFA) completed the structured adapted interview along with 40 healthy controls (match by education, sex and age) and 45 Alzheimer's disease patients. The adapted version allowed the detection of behavioral symptoms and language impairment not captured by the original version of the CDR scale, assigning also staging, useful for determining severity disease. Conclusions: The results support the usefulness of the tool in the detection of the typical symptoms of the frontotemporal dementia complex as well as the ability of the scale to assign staging and severity of the disease.




Buyatti, D., Russo, G., Bagnati, P., Campos, J., Amengual, A., Cohen, G., & Allegri, R. (2013). O2-03-03: Utility of the Spanish version of the FTLD-modified CDR in the diagnosis and staging of frontotemporal dementia complex. Alzheimer’s & Dementia, 9, P320–P321. https://doi.org/10.1016/j.jalz.2013.04.149

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