Non-conventional modification of low density lipoproteins: Chemical models for macrophage recognition of oxidized LDL

11Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

To define the structural and chemical criteria governing recognition of oxidized LDL (oxLDL) by mouse peritoneal macrophages (MPM), we exposed LDL to novel chemical modification agents that induce defined neutralizing and non- neutralizing alterations of lysine as models for distinct apoB adducts present in oxLDL. We found some exceptions to the usual notion that neutralization of lysine positive charges is the principal determinant governing MPM recognition. In addition, competitive binding experiments using chemically modified 125I-LDL preparations revealed that, whereas some modifications engendered recognition principally by the classical scavenger receptor class A (SRA), as seen for acetylated LDL (acLDL), chemical models of advanced aldehydic modifications of LDL led instead to MPM uptake mainly by oxLDL receptors distinct from SRA.

Cite

CITATION STYLE

APA

Hoppe, G., O’Neil, J., Sayre, L. M., & Hoff, H. F. (1997). Non-conventional modification of low density lipoproteins: Chemical models for macrophage recognition of oxidized LDL. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1362(2–3), 103–108. https://doi.org/10.1016/S0925-4439(97)00091-4

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free