Biological activity of phenothiazine sulfonamides

Abstract

Background: Antibacterial activities in “dimethylsulfoxide (DMSO)" were executed by the broth dilution method utilizing nutrient agar. By using the agar cup bioassay method antifungal activities were calculated with “Clotrimazole” as the standard. The novel compounds 1a-j have been evaluated in vitro for their antibacterial activity by “Gram-positive bacteria namely Bacillus subtilis, Bacillus sphaericus and Staphylococcus aureus and three Gram-negative bacteria Pseudomonas aeruginosa”, “Klebsiella aerogenes and Chromobacterium violaceum”. All ten compounds were analysed for their antifungal activity against five test “organisms Aspergillus niger, Chrysosporium tropicum, Rhizopus oryzae, Fusarium moniliforme and Curvularia lunata”. Among the isolated compounds 1d and 1e evinced dynamic Movement towards both gram certain What’s more gram negative microscopic organisms. Mixes 1d Also 1f uncovered useful antifungal action. All the secluded compounds were scrutinized for their antibacterial and antifungal activities and most of the compounds manifested remarkable anti bacterial and anti fungal activity.