E-cadherin plays a major role in cell-cell adhesion and inactivating germline mutations in its encoding gene predispose to hereditary diffuse gastric cancer. Evidence indicates that aside from its recognized role in early tumourigenesis, E-cadherin is also pivotal for tumour progression, including invasion and metastization. Herein, we discuss E-cadherin alterations found in a cancer context, associated cellular effects and signalling pathways, and we raise new key questions that will impact in the management of GC patients and families. © 2012 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
Carneiro, P., Fernandes, M. S., Figueiredo, J., Caldeira, J., Carvalho, J., Pinheiro, H., … Seruca, R. (2012). E-cadherin dysfunction in gastric cancer - Cellular consequences, clinical applications and open questions. In FEBS Letters (Vol. 586, pp. 2981–2989). https://doi.org/10.1016/j.febslet.2012.07.045