The anti-osteoporotic effect of Moringa oliefera on osteoblastic cells: SaOS 2

Abstract

M.oliefera oliefera (MO) is a middle-sized tree, cultivated throughout India. It is a multipurpose tree, used as a vegetable, spice, a source of cooking and cosmetic oil and as a medicinal plant. It is reported to contain alkaloids, flavonoids, anthocyanins. It possesses anti-inflammatory, antioxidant, antimicrobial, antihyperlipidaemic, antifertility and anticancer activities. An in-vivo study in our laboratory has proved the osteoprotective potential of the plant. In the present study an attempt is made to explore the osteoblastogenic potential of the different parts of the plant on the osteoblast cell line SaOS2. Methanolic extracts of MO components showed a positive effect, and of all the three components, flower and fruit were found to have significant osteoblast stimulating property. Flower extract was found to be increasing the number of osteoblastic cells; while the fruit extract was having more elaborative effect as it increased ALP activity, induced bone formation, increased hydroxyproline content and bone mineral formation. In conclusion, Methanolic Extact of MO on SaOS2 cell line affirmed the beneficial effects and thus indicates its potential in preventing osteoporosis. Keywords- MO, MO Flower, MO Fruit, MO Leaves, Moringa oliefera, Osteoblasts, SaOS2