A mild, copper-catalysed amide deprotection strategy: Use of tert-butyl as a protecting group

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Abstract

Mild methods for the deprotection of organic substrates are of fundamental importance in synthetic chemistry. A new room temperature method using a catalytic amount of Cu(OTf)2is reported. This allows use of the tert-butyl group as an amide protecting group. The methodology is also extended to Boc-deprotection.

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Evans, V., Mahon, M. F., & Webster, R. L. (2014). A mild, copper-catalysed amide deprotection strategy: Use of tert-butyl as a protecting group. Tetrahedron, 70(41), 7593–7597. https://doi.org/10.1016/j.tet.2014.07.080

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