Abstract
Herbert et al reported association with obesity of a common DNA variant rs7566605 at 10kb upstream of the INSIG2 gene. We analyzed rs7566605 polymorphism in 3125 Chinese in a cross-sectional study. We found no significant association of rs7566605 polymorphism with body mass index (BMI) and waist circumference among all participants (P=0.52). However, if geographic location is considered, the C/C genotype of rs7566605 was marginally associated with increased levels of BMI and risk of obesity among individuals living in Shanghai (P=0.06), indicating that the C/C genotype may contribute to obesity in certain subpopulation among Chinese under certain environmental settings.
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Yang, L., Wu, Y., Li, H., Yu, Z., Li, X., Liu, Y., … Chen, Y. (2008). Potential association of INSIG2 rs7566605 polymorphism with body weight in a Chinese subpopulation. European Journal of Human Genetics, 16(6), 759–761. https://doi.org/10.1038/ejhg.2008.8
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