Variantes genéticas de CYP2A6 y su relación con la dependencia tabáquica y el hábito de fumar en una muestra individuos chilenos. Un estudio piloto

0Citations
Citations of this article
7Readers
Mendeley users who have this article in their library.

Abstract

Background: Genetic and metabolic factors associated with nicotine metabolism may be related to smoking behavior. Aim: To assess the prevalence of allelic and genotype variants of CYP2A6 in a sample of Chilean subjects and to evaluate their relationship with smoking and tobacco dependence. Material and Methods: The genotype frequencies for *2, *3 and *4 of CYP2A6*1 (wild type) gene were determined by polymerase chain reaction (PCR) in 54 volunteers. Addiction to tobacco was evaluated using the Fagerström Test. The association between the presence of allelic variants of CYP2A6 and smoking and tobacco dependence was evaluated with chi square test. Results: The prevalence of *1, *2 (wt/*2), *3 (wt/*3 or *3/*3) and *4 (del/del) were 92.6%, 3.7%, 0% y 3.7%, respectively. No signifi cant association was observed between being a carrier of a variant genotype of CYP2A6 and smoking or tobacco dependence. Conclusions: In this sample of Chilean individuals we did not fi nd a relation between any CYP2A6 genotype with smoking or tobacco dependence.

Cite

CITATION STYLE

APA

Lillo Cáceres, D. D., Alvarado, S. A., Martínez, P., & Quiñones, L. A. (2012). Variantes genéticas de CYP2A6 y su relación con la dependencia tabáquica y el hábito de fumar en una muestra individuos chilenos. Un estudio piloto. Revista Medica de Chile, 140(4), 436–441. https://doi.org/10.4067/S0034-98872012000400003

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free