The Arf-Mdm2-p53 tumor suppressor pathway is activated by sustained hyperproliferative signals emanating from oncoproteins such as Myc. A recent study reveals a novel level of feedback control, whereby induced p19 Arf binds to Myc and blocks cell proliferation by selectively impairing its transactivation functions.
Cleveland, J. L., & Sherr, C. J. (2004). Antagonism of Myc functions by Arf. Cancer Cell. Cell Press. https://doi.org/10.1016/j.ccr.2004.09.020