Multienzyme One-Pot Cascade for the Stereoselective Hydroxyethyl Functionalization of Substituted Phenols

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Abstract

The operability and substrate scope of a redesigned vinylphenol hydratase as a single biocatalyst or as part of multienzyme cascades using either substituted coumaric acids or phenols as stable, cheap, and readily available substrates are reported.

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Payer, S. E., Pollak, H., Schmidbauer, B., Hamm, F., Juričić, F., Faber, K., & Glueck, S. M. (2018). Multienzyme One-Pot Cascade for the Stereoselective Hydroxyethyl Functionalization of Substituted Phenols. Organic Letters, 20(17), 5139–5143. https://doi.org/10.1021/acs.orglett.8b02058

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