Association between serum magnesium and blood lipids: Influence of type 2 diabetes and central obesity

Abstract

To assess the changes in the relationship between serum Mg and blood lipids of Chinese adults with type 2 diabetes (T2D) or central obesity, a total of 8163 subjects (mean age 59.6 years, 54.9 % men) were analysed. Participants were classified according to blood Mg (below 0.65 mmol/l, 0.65-0.95 mmol/l and above 0.95 mmol/l), T2D (yes/no) and central obesity (yes/no). Blood lipids (TAG, total cholesterol (TC), HDL-cholesterol and LDL-cholesterol) were determined by standardised methods and conditions. A significant increase in blood lipids, with the exception of HDL-cholesterol, across progressive Mg groups in all subjects was noted (P<0.05). TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with central obesity compared with those without central obesity (P<0.05). A significant increase in TAG, TC and LDL-cholesterol across progressive Mg groups was observed in subjects without T2D (P<0.05). However, no significant change of HDL-cholesterol and LDL-cholesterol across progressive Mg groups was observed in subjects with T2D (P>0.05). TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with T2D than those without T2D (P<0.05). Multivariable models for TAG and LDL-cholesterol failed to attain statistical significance in diabetics, by using a generalised linear or parsimonious model. TAG, TC, HDL-cholesterol and LDL-cholesterol were significantly higher among subjects with T2D or central obesity. Blood lipids, with the exception of HDL-cholesterol, were associated with serum Mg, but this association was somehow influenced by T2D in LDL-cholesterol. In addition, multivariable models for both TAG and LDL-cholesterol failed to attain statistical significance among subjects with T2D, different from subjects without T2D.