Influence of strontium dopant on bioactivity and osteoblast activity of spray pyrolyzed strontium-doped mesoporous bioactive glasses.

Abstract

With the emerging development of bioactive materials, mesoporous bioactive glasses (MBGs) are regarded as potential candidates for bone and tissue engineering due to its high surface area. In the present work, spray pyrolyzed MBGs doped with Strontium (Sr), an ion which promotes osteoblast bone-forming activity, were prepared. While the phase information, particle morphology, porous structure, and specific surface area were characterized by X-ray diffractometer, scanning electron microscope, transmission electron microscope, and nitrogen adsorption/desorption isotherm, respectively. In addition, in vitro bioactivity was examined following Kokubo’s protocol while the osteoblast activity was examined by alkaline phosphatase (ALP) assays. Finally, the results indicate that MBG specimens with optimal Sr dopant can enhance bioactivity and osteoblast activity and corresponded mechanisms were discussed.